Proceedings of the Third Joint Symposium on Neuroacanthocytosis and Neurodegeneration with Brain Iron Accumulation: From Benchside to Bedside
نویسندگان
چکیده
Erythrocyte structure and function depend upon interactions between proteins in and associated with the membrane, centered around band 3. This protein harbours physiological removal signals and, as a main component of the links between the cytoskeleton and the lipid bilayer, plays a central role in deformability. Also, as a binding partner of hemoglobin and key glycolysis enzymes, band 3 is the link between the oxygendependent trade-off between ATP production and NADPH-mediated protection against oxidative damage. Phosphorylation of band 3 by Lyn and Syk kinases is involved in the regulation of these processes.
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